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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name PRR siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods siRNA transfection, qRT-PCR, immunoblot
Expression pattern associated
Functional description We demonstrated that small interfering RNA (siRNA)-mediated knockdown of PRR, Nox2 and Nox4 significantly reduced the HG-induced stimulation of VEGF.
PubMed ID 28840773
Year 2017
Title Prorenin receptor (PRR)-mediated NADPH oxidase (Nox) signaling regulates VEGF synthesis under hyperglycemic condition in ARPE-19 cells.
Drug-related ncRNA NO

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